Genomics euphoria: ramblings of a scientist on genetics, genomics and the meaning of life

Monthly Archives: April 2015

RNA Structurome (part II)

Recently, two very great papers came out in Nature that I urge you to read:

1. The icSHAPE method, developed by the Howard Chang’s group at Stanford, which I think is the gold-standard for in vivo RNA structurome data.

2. The hiCLIP method that provides a principled approach for looking at interactions with dsRNA binding proteins. For example, this would have been very helpful for our work on the dsRBP TARBP2.

In general, I’m quite excited by the technologies that are now available for probing the structural component of RNA and really gauge its importance in RNA-mediated interactions and RNA biology in general.